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acad. Ivan Pavlov
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phone: (812) 2349937 The I.P. Pavlov physiological Department was the first department organized at the Imperial Institute of Experimental Medicine and since 1891 it was headed by Professor I.P. Pavlov, who later became academician and a Nobel prize winner. The researches that have enriched the world science with the ideas of work of the digestive tract and functions of its large glands were fulfilled with I.P. Pavlov's direct participation. The conditioned reflexes were also discovered and the doctrine of higher nervous activity was created, which presently inseminates scientific ideas in psychology, psychiatry and neurophysiology.
After I.P. Pavlov the Department was headed by professors L.A.Orbeli for short period and later the investigation of main regularities of higher nervous activity of animals and man was continued under the supervision of P.I. Kupalov and since 1965 - under M.M. Khananashvili. M.M. Khananashvili formulated the main conception of integrated systems of conditioned reflexes as functional units of the systemic behaviour as well as on the animal and human conception of informational neuroses and ways of the prevention and treatment of them. In 1978-1995 the Department was headed by G.A. Vartanyan. The scientists’ attention was concentrated on elaboration of "locking" problem on different models as well as on a nervous process analysis in the brain in the course of formation of various conditioned reflexes. Since 1995 the Department has been headed by professor doctor of medical sciences V.M. Klimenko.
Traditionally, the main direction of the researches of the Department for more than a hundred years has been investigations of the mechanisms of integrative activity of the brain. Special attention has been given to studying interrelationships between organism and environment, the processing of sensory information, its significance for social experiences and, more broadly, the normal, and pathological mechanisms of activity of the central nervous system. During the recent decade the Department has been performing investigations in the field of interactions between cells of the brain, its structures, mechanisms of adaptive behavioral reactions of the animal and man to the influence of various external and internal factors. The investigations of neurobiological bases of the afferent structure of neuroimmune interaction resulted in obtaining priority data on the mechanisms of the brain response to activation of the immune system, involvement of immunogenic factors in the formation of adaptive behavior and in the regulation of normal physiological functions.
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