Faina Michailovna  Zakharova  Ph.D.

Department of Molecular Genetics,
Institute of Experimental Medicine Russian Academy of Medical Sciences,
Acad. Pavlov st., 12,  St.-Petersburg
197376, RUSSIA

Tel: +7 812 2343356; Fax: +7 812 2349489
E-mail: zakharova@vz5518.spb.edu

Date of Birth: November 20, 1973

Field of Expertise:
Molecular Genetics. Study of mutations and polymorphisms in St.-Petersburg patients with familial hypercholesterolemia. Study of possible linkage between polymorphism's alleles and development of familial hypercholesterolemia by comparison of polymorphism allele frequencies in normal and familial hypercholesterolemia subjects.

Specialities by experience:
- Extracting DNA from blood;
- Polymerase chain reaction (PCR);
- Agarose and polyacrylamide electrophoresis;
- SSCP and heteroduplex analysis;
- Gel-filtration chromatography;
- Manual DNA sequencing.

Education:
1991-1998: Department of Biophysics, Faculty of Physics and Mechanics, St.-Petersburg State Technical University, St.-Petersburg, Russia
1996: B.Sc. - Physics
1998: M.Sc. - Biophysics
1998-2001 - Ph.D. student at Department of Molecular Genetics, Institute of Experimental Medicine Russian Academy of Medicine Sciences, St.-Petersburg, Russia
2001: Ph.D. - Biochemistry. Ph.D. thesis entitled: "Genetic variability of low density lipoprotein receptor gene in St.Petersburg population"

Work Experience:
1995-present: Department of Molecular Genetics, Institute of Experimental Medicine Russian Academy of Medicine Sciences, St.-Petersburg, Russia. Established position as a Research Scientist since 2001.

Awards:
1. 1998-2001: St.-Petersburg Municipal Scholarship for young scientists;
2. 2000: Personal grant of International Soros Science Education Program (the title "Soros Graduate Student Grantee").

List of Publications

Papers:

• Chakir Kh., Mandelshtam M.Ju., Shevtsov S.P., Golubkov V.I., Skobeleva N.A., Schur Yu.A., Zakharova F.M., Lipovetskyi B.M., Konstantinov V.O., Denisenko A.D., Gaitskhoki V.S., Schwartz E.I. (1998) Two novel low density lipoprotein receptor gene mutations (E397X and 347delGCC) in St.Petersburg familial hypercholesterolemia. Molecular Genetics and Metabolism 65 (4), 311-314
  
• Mandelshtam M.Ju., Chakir Kh., Shevtsov S.P., Golubkov, V.I., Skobeleva, N.A., Schur Yu.A., Zakharova F.M., Kudinov S.I., Volkova M.V., Baranovskaya S.S., Demidova D.V., Sverdlova A.M., Lipovetskyi B.M., Konstantinov V.O., Denisenko A.D., Gaitskhoki V.S., Schwartz E.I. (1999) Study of familial hypercholesterolemia molecular genetic basis in St.Petersburg. Arterial hypertension 5 (1), 40-41 (in Russian iournal, without English summary).
  
• Mandelshtam M.Ju., Golubkov, V.I., Tatishcheva Yu.A., Zakharova F.M., Chakir Kh., Shevtsov S.P., Skobeleva, N.A., Lipovetskyi B.M., Konstantinov V.O., Denisenko A.D., Maslennikov A.B., Gaitskhoki V.S., Schwartz E.I. (2002) Molecular genetics of familial hypercholesterolemia: present state of the problem in Russia. Pacific Medical Journal 1 (8), 10-11 (in Russian iournal, without English summary).
  
• Zakharova F.M., Golubkov V.I., Mandelshtam M.Ju., Lipovetskii B.M., Gaitskhoki V.S. (2001) Identification of novel missense mutation G571E, novel silent mutation H229H, nonsense mutation C74X, and four single nucleotide polymorphisms in the low-density lipoprotein receptor gene in patients with familial hypercholesterolemia from St. Petersburg. Russian Journal of Bioorganic Chemistry 27 (5), 349-351 (in English, translated from Russian edition).

Abstracts:

• Iroshnikova F. (Zakharova F.M.), Schur J., Chakir, K., Mandelshtam M. Identification of mutations causing familial hypercholesterolemia in St.-Petersburg. International Medical Conference for students and young doctors, Lublin, Poland, April 24-26, 1998, Abstract Book, 39
  
• Tatishcheva Yu.A., Zakharova F.M. Study of the mutations causing familial hypercholesterolemia in St.-Petersburg. 10th International Congress of Human Genetics, May 15-19, 2001, Vienna, Austria. Programme and Abstracts. European Journal of Human Genetics 9, Suppl. 1, 278
  
• Zakharova F.M. Genetic counselling in families with familial hypercholesterolemia. 12th European Students' Conference for Medical Students and Young Doctors at Charite, Berlin, November, 21st-25th 2001, Abstract Book, 160

15 Abstracts in Russian were published in addition.