|
|
Laboratory of Neuroimmunomodulation |
|
|
|
Laboratory of Neuroimmunomodulation |
|
|
|
The main trend in scientific studies of the laboratory of NeuroImmunoModulation is the investigation of molecular mechanisms of the cytokine Interleukin-1 interaction with immune-competent and nerve target cells and further intracellular transduction of its signal via the sphingomyelin pathway. The results obtained allowed to experimentally ground the concept suggesting similarity in the sphingomyelin pathway of Interleukin-1 signalling for immune-competent and nerve cells, as well as for actrocytes. The principle necessity of Interleukin-1 binding with its receptor type I for activation of neutral sphingomyelinase – the key enzyme of the sphingomyelin cascade – and initiation of this signalling pathway, has been found. It was shown for the first time, that the sphingomyelin pathway of Interleukin-1 signalling is a common link in reaction of cells of the central nervous and immune systems on stress. Modulating action of glucocorticoid hormones, pituitary hormone prolactin and short synthetic peptides on Interleukin-1 signal transduction via the sphingomyelin pathway was established.
|
Head
- Elena G.Rybakina, 
The
results of priority experiments of ligand-receptor and signalling
mechanisms of neuro-immune interactions allowed to conclude, that
changes in the intensity of Interleukin-1 signalling in nerve and
immune-competent cells is an informative indicator of development of
different stress- induced disorders of host defense functions. The novel
data concerning immunoprotective effects of Interleukin-1 and prolactin
under stress conditions, as well as gero- and stress-protective effects
of immunomodulating short peptides have been obtained. The functional
test system enable to evaluate the level of activity of host defense
reactions during stress and different forms of pathology was developed.