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Irina
Solomonovna
Freidlin
Freidlin Irina Solomonovna born
1936, graduated from the 1st Leningrad Medical Institute named by
I.P.Pavlov in 1959, doctor of medical sciences (1976), professor of
microbiology, virology and immunology (1989). The honored scientist of the
Russian Federation
(1997). From 1991 - chairman of the Department of immunology of the
Institute of experimental medicine RAMS, at the same time - professor at
the Department of microbiology, virology and immunology of St.-Petersburg
State Pavlov Medical University.
I.S.Freidlin is the author of 210
published scientific works (162 of them in co-authorship), including 4
monographs (3 in co-authorship), 4 manuals (3 in co-authorship), a
reference book (in co-authorship) and 2 textbooks (both in
co-authorship). I.S.Freidlin has made 4 inventions and is the holder of
2 patents.
Her main research interests include
studying the problems of fundamental, infectious, clinical and ecological
immunology. Freidlin I.S. is the leading domestic expert on mononuclear
phagocytes system. She showed that macrophages and proinflammatory
cytokines play a dual role in anti-infectious defense: they may both
fulfill protective functions and take part in alteration. I.S.Freidlin
first showed the possibility of purposeful regulation of macrophage
function. She detected short peptide sequences, contained in the
structures of natural bioregulators, including proinflammatory cytokines,
which mimiced activating effects of the whole molecules.
In joint research project with
clinicians she offered pathogenetically based approaches to the choice of
immunological tests and interpretation of their results. She developed new
methods, which can be used for the estimation of the functional activity
of blood monocytes from patients with different diseases. She also showed
high self-descriptiveness of the assessment of cytokine status.
I.S.Freidlin research works in
ecological immunology identified parts of the immune system most sensitive
to the influence of adverse factors: aggressive gases and ionizing
radiation.
I.S.Freidlin has been a supervisor of 6 doctoral and 26 "candidate"
dissertations.
I.S.Freidlin is a vice-president of
St.-Petersburg branch of Russian scientific society of immunologists, a
member of a steering committee of the Russian scientific society of
immunologists and a member of editorial boards of scientific journals
"Immunology", «Russian Journal of Immunology» and "Allergology".
The list of doctoral and "candidate
of of sciences" dissertations prepared under the supervision or scientific
consultation of I.S.Freidlin
Doctoral dissertations:
1. Krasilnikova E.I. A role of hyperinsulinemia in the pathogenesis of
atherosclerosis in patients with ischemic heart disease and diabetes
mellitus. Ways of prophylaxis and treatment. Scientific advisers:
I.S.Freidlin and J.V.Blagosklonnaja (endocrinology), 1991.
2. Sokolovskij E.V. Serologic
resistance after treatment of lues. Scientific advisers: I.S.Freidlin and
I.M.Raznatovsky (dermal and venereal disease), 1995.
3. Selkov S.A. Immunological aspects
of pregnancy noncarrying. Scientific advisers: I.S.Freidlin and
E.K.Ajlamazjan (Obstetrics and gynecology), 1996.
4. Totoljan A.A. Pathogenetic
approach to laboratory diagnostics of immunopathological conditions
Scientific adviser: I.S.Freidlin, 1997.
5. Kiseleva E.P. Mechanisms of
thymus involution and mononuclear phagocytes activation
of in experimental tumours, Scientific adviser: I.S.Freidlin, 2002.
6. Kitiashvili I.Z. The influence
of surgical operation and anesthesia upon immune system - cells
activity. 2006.
"Candidate of sciences"
dissertations (PhD):
1. Artemenko N.K. Influence of some anti-viral drugs on the production of
phage-neutralizing antibodies by the organism and functional activity of
macrophages in tissue cultures. 1973.
2. Zveibach A.S. Some characteristics of Ò and B lymphocytes from the
blood of healthy persons and patients with lymphoproliferative diseases.
1979.
3. Ignatova G.L. Changes in the parameters of nonspecific resistance and
immune system in patients with pneumonias. 1980.
4. Vysochina L.V. Clinical and immunological comparisons in acute and
chronic viral hepatitis in children. 1980.
5. Kravtsov V.D. A role of macrophage secretory products in the
self-regulation of mononuclear phagocytosis system in acute inflammation.
1981.
6. Tejber E.L. Mobilization and functional rearrangement of mononuclear
phagocytes under the influence of enterobacterial cultures filtrates.
1982.
7. Zalevskaja A.G. Some parameters of cellular immunity in patients with
diabetes and obesity. 1983.
8. Gorbacheva I.À. Changes of immunological parameters in patients with
pneumonia on different treatment regimens. 1986.
9. Totoljan A.A. Some parameters of cellular and humoral immunity in
patients with bronchial asthma during treatment. 1986.
10. Romantsov M.G. Course of acute and chronic hepatitis B infection:
clinical and immunological comparisons. 1986.
11. Popova I.A. Clinical and pathological significance of 1-thymosin in
children with hepatitis B infection. 1991.
12. Vishnevetskij R.F. Long persistance of Mycobacterium leprae in cells
of macrophage-like cell line P.388D1. of 1993.
13. Totoljan N.A. Clinical and immunological comparisons in patients with
multiple sclerosis. 1993.
14. Pafifova A.S. Cellular reactions of CSF in purulent meningitis in
children. 1993.
15. Bondarev I.E. Interaction of alpha-2-macroglobulin with TNFa. 1995.
16. Kostjukova S.B. Study of immunoglobulins concentrations in laryngeal
fluid in patients with chronic hyperplastic laryngitis in comparison with
healthy persons. 1996.
17. Mironova Z.G. Characteristic features of clinical course, formation of
postvaccinal immunity and a the role of cytokines in its regulation in
children with nervous system disease, vaccinated against diphtheria and
measles. 1996.
18. Konjaev I.G. Comparison of biological effects of TNFa and synthetic
oligopeptides, corresponding to the fragments of TNFa molecule. 1996.
19. Nikitina U.J. Ability of mononuclear phagocytes and endothelial cells
to secret TNFa in response to atherogenic stimuli. 1997.
20. Malyshkin K.A. Immunological changes in alimentary insufficiency and
immunocorrecting effects of alimentary additives. 1998.
21. Kuznetsova S.A. Influence of immune complexes on cytokine production
by blood cells and on the expression of surface markers of endothelial
cells activation. 2000.
22. Sokolov D.I. Influence of cytokines and their combinations on the
expression of surface molecules and chemokine IL-8 secretion by ECV304
endothelial cells. 2001.
23. Sheikine Y.A. Regulation of macrophage activity in atherosclerotic
lesions by gammaIFN. 2002.
24. Tendler E.V. The role of immunological mechanisms in development
anticancer effect of antibody to protein p53. 2005.
25. Starickova E.A. The interaction of mononuclear phagocytes with
endothelial cells: the role of cytokines. 2006.
26. Kissina T.E. "Studying of individual fitches of mononuclear cells of
tuberculosis patients" (2006)
27. Amchislavskiy E.I. "Studying of the influence of cytokines on the
functions of human endothelial cells of EA.Hy.926 line" (2006)
Received research grants:
1. Grant of the Russian Fund of Fundamental Investigations (RFFI) _
94-04-11796-a (1994-1996 a.a.)., principal investigator
2. Grant of the Russian Fund of Fundamental Investigations (RFFI) _
97-04-48889 (1997 - 2000 a.a), principal investigator
3. Grant of the Russian Fund of Fundamental Investigations (RFFI) _
00-04-48064 (2000 - 2003 a.a.), principal investigator
4. Grant of Russian Fund of Fundamental Investigations (RFFI) -
03-04-48118 (2003 - 2005 a.a.), principal investigator
5. Grant of President of Russian Federation NSH-540.2003.4 (2003
-2005 a.a.)
6. Grant of Russian Fund of Fundamental Investigations (RFFI)
06-04-48110 (2006-2008) |
