Prevention of bacterial infections, mixt infections, probiotics

 The recombinant peptides corresponding to different sites of surface GBS proteins (Bac and ScaA) and genetical constructions made on their basis that code the successive sites of the N-terminal portions of these proteins allowed detection of domens responsible for different functions of proteins (immune response, binding immunoglobulin A, cocci aggregation). This data are important for the fine analysis of the immunological features of the recombinant peptides ( IgG titers, affinty of antibodies, protection in vitro and in vivo) which is important for construction of vaccines against GBS.

 A connection was shown between the level of adhesion of group A pathogenic streptococci (GAS) to tissues and synthesis of proteins in the microbial cell wall. Investigations of the role of group B streptococci (GBS) in the pathology of pregnancy have shown that the level of their tropism to the labor pathway epithelium is regulated by the menstrual cycle mechanisms — it grows at hormonal contraception thus increasing the risk of the development of pathological processes during pregnancy and labor. The leading role of viral infections (influenza) was established in the formation of mixed (influenza virus and streptococcus) infections of the respiratory system. It was shown that virus-specific syntheses in mammalian cells modified cell membranes and thus increased the receptive field for adhesion of streptococci. A considerable cycle of works has been performed on studying the Fc binding of immunoglobulins G with pathogenic streptococci. The sum of these results became a stage for further studying the mechanisms of streptococcal processes.

 In order to investigate the nature of antimicrobial activity of lactic acid bacteria several strains of lactobacilli, enterococci and lactococci have been studied in different microbiological models for ability to inhibit growth of pathogenic bacteria. These probiotic strains expressing several bacteriocins are under study now in order to understand the nature and spectrum of bacteriocin activity